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Those with cancer restricted entirely to the esophageal mucosa have about an 80% 5YSR, but submucosal involvement brings this down to less than 50%

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These cytokines, along with neurotrophic factors such as brain-derived neurotrophic factor, nerve growth factor, and vascular endothelial growth factor, all exacerbate the state of chronic inflammation in the CNS (Ashraf-Uz-Zaman et al., 2022)

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